My Char so far is a dual-greatsword toting firebreathing woodelf of destruction.....
You can Multiclass upto FOUR classes in NWN2 and I took advantage of that (lvl 16 so far):
1lvl bard - Chant gives a +1 to attack, +1 magic and +1 bludg damage to each hand.
1lvl NWN Nine - Aura gives +2 save and +1 AC to all party members, plus lets you wear NWN9 gear.
4lvl Fighter (currently) will be 8lvl when char is finished @ lvl 20.
10lvl Red Dragon Disciple - fire/paralysis/sleep/fear immunity, breath fire, High Fort and Will Saves, + Various Attributes (+ALOT of Str), +AC due to scaly skin.
Spec'd Dual Weild + Monkey Grip, Greatsword focus, Toughness, Knockdown, Dodge, Heavy armor, etc.
I have a ring that gives free Improved Evasion feat, not to mention I maxed my str thru RDDisciple and gear so I now have 30 str.
High + bonus weps and (*spoiler follows*) if you spar against the knight that takes you in as a squire you can get an additional +1 to attack with all melee weps bonus... That coupled with the bard chant bonus helps offset the -2 atr you get from weilding a 2h wep in one hand, thx to monkey grip
RRDisciple gets 12 hp's per lvl and fighter gets +10, add in toughness = High HP's. Currently wearing some medium dragon armor so that I can still keep my Dex +3 bonus, which makes my AC decent at 28 (or is it 29?) but not insanely high as heavy + a shield can get you.